This breakout session addresses the unfortunate incidences of burnout and premature return from the place of ministry for both short-term and long-term medical missionaries. The world in which we live is increasingly complex. Issues of safety and security have become significant in many of the places where medical missionaries are needed most. Yet, the pressures of the work, relationships and other challenges continue to undermine the longevity, joy, and capacity to thrive for medical missionaries. We must examine what is going on and collaboratively seek wise responses to the challenges, for the sake of both the lost and the called.